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RESEARCH My primary goal is to identify the factors required for somatic homolog pairing. I am using FISH to conduct genome-wide RNAi-driven screens for mutants that alter the fidelity of homolog pairing in Drosophila and then will characterize the genetic pathways that are identified. To address cancer directly, I am also working with Brian Beliveau to generate low-cost high-resolution chromosome paints that will permit analyses of human tumor types and cell lines as well as a screen of the human genome for pairing factors. PUBLICATIONS A Pathway for Synapsis Initiation during Zygotene in Drosophila Oocytes. Drosophila ATM and ATR have distinct activities in the regulation of meiotic DNA damage and repair. Meiotic checkpoints and the interchromosomal effect on crossing over in Drosophila females. Drosophila I-R hybrid dysgenesis is associated with catastrophic meiosis and abnormal zygote formation. Chromosome axis defects induce a checkpoint-mediated delay and interchromosomal effect on crossing over during Drosophila meiosis. Cytological analysis of meiosis in fixed Drosophila ovaries. Drosophila hold'em is required for a subset of meiotic crossovers and interacts with the dna repair endonuclease complex subunits MEI-9 and ERCC1. Drosophila PCH2 is required for a pachytene checkpoint that monitors double-strand-break-independent events leading to meiotic crossover formation. When specialized sites are important for synapsis and the distribution of crossovers.
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